Sandra A Rempel, BSc PhD

Biomedical Science Editing and Writing

Writing

A scientific career involves so much writing! I have written award-receiving NIH and Foundation grant proposals that provided the funds to support my research. I have written textbook chapters, journal reviews, and peer-reviewed journal articles. A few of these are highlighted. For more information, please see my CV.

Awarded Grants

NIH-NCI R01 – Principal Investigator

NIH ARRA – Co-Investigator

NIH-NCI R01 – Principal Investigator

NIH-NCI R01 – Co-Principal Investigator

NIH-NCI Biology Core Allocation – Principal Investigator

NIH-NCI R21 – Principal Investigator

James S. McDonnell Foundation Program in Brain Cancer Research – Principal Investigator

Pediatric Brain Tumor Foundation of the United States – Principal Investigator

NIH-NINDS R01 – Collaborator

NIH-NCI R01 – Co-Principal Investigator

Elsa U. Pardee Foundation – Principal Investigator

Wayne State University Undergraduates Research and Creative Projects Award – Mentor

Wayne State University Undergraduates Research and Creative Projects Award – Mentor

Wayne State University Undergraduates Research and Creative Projects Award – Mentor

Jeffery Baron/American Brain Tumor Association Fellowship – Mentor

 

 

Selected Peer-reviewed Publications

(click here to download CV for entire portfolio)

 

Thomas SL, Schultz CR, Mouzon E, Golembieski WA, El Naili R, Radakrishnan A, Lemke N, Poisson LM, Gutiérrez JA, Cottingham S, Rempel SA. Loss of Sparc in p53-null astrocytes promotes macrophage activation and phagocytosis resulting in decreased tumor size and tumor cell survival. Brain Pathol. 2015 Jul;25(4):391-400. doi: 10.1111/bpa.12161. Epub 2015 Apr 20. PMID: 24862407

 

Alam R, Schultz CR, Golembieski W, Rempel SA. PTEN Suppression of SPARC-induced migration of glioma cells correlates with the suppression of pP38 MAPK and pMAPKAPK2 and the differential regulation of HSP27 phosphorylation and expression. Neuro Oncol. 2013 Apr;15(4):451-61. doi: 10.1093/neuonc/nos326. Epub 2013 Feb 3.PMID: 2338228

 

Schultz CR, Golembieski WA, King DA, Brown SL, Brodie C, Rempel SA. Inhibition of HSP27 alone, or in combination with pAKT inhibition, as therapeutic approaches to target SPARC-induced glioma survival. Mol Cancer. 2012 Apr 5;11:20. doi: 10.1186/1476-4598-11-20. PMID: 22480225

 

McClung HM, Golembieski W, Schultz CR, Rempel SA. Deletion of the SPARC Acidic Domain or EGF-like Module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma. Carcinogenesis. 2012 Feb;33(2):275-84. doi: 10.1093/carcin/bgr276. Epub 2011 Nov 23. PMID: 22114076

 

Thomas SL, Alam R, Lemke N, Schultz LR, Gutiérrez JA, Rempel SA. PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling. Neuro Oncol. 2010 Sep;12(9):941-55. doi: 10.1093/neuonc/noq048. Epub 2010 May 14. PMID: 20472716

 

Golembieski W, Thomas SL, Schultz CR, Yunker CK, McClung H, Cazacu S, Barker T, Sage EH, Brodie C, Rempel SA. HSP27 mediates SPARC-induced changes in glioma morphology, migration and invasion. Glia. 2008 Aug 1;56(10):1061-75. doi: 10.1002/glia.20679. PMID: 18442089

 

 

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